Valerian Root Extract is:
1. A general tranquilizer used for relieving nervous tension, insomnia and headache.
2. It is Anti-anxiety, anti-stress.
4. Menopausal disturbances.
5. Nervine tonic.
6. Nervous gastralgia.
Uses and Advance Studies:
|Product||Valerian Wallichii Dry Extract.|
|Description||Dark brown coloured powder with Characteristic odour.|
|Test Solution||Dissolve 0.25 g. extract in 25 ml pure methanol by warming on a water bath, filter and concentrate to 5ml.|
|Solvent System||Toluene-Ethyl Acetate (93:7)|
|Spray Reagent||Hydrochloric acid-Acetate Acid reagent.|
|Evaluation||The TLC picture of Extract is identical with that of standard Valerian Root (Three blue spots).|
Toxicity and Safety Aspects:
Valerian Root Extract has been reported to be safe, however, low order toxicity has been reported for an ethanolic extract. When extract was administered intraperitoneally to rats in a dose of 400 mg – 600 mg/kg daily for 45 days, no significant changes in weight, blood and urine were observed.
When Valerenic acid was given intraperitonelly to mice, the following results were observed.
50 mg/kg reduced spontaneous motility.
100 mg/kg caused ataxia.
150-200 mg/kg caused muscle spasm.
400 mg/kg caused heavy convulsions leading to death.
LD-50 of extract in mice by intraperitoneal injection 3.3 g/kg.
LD-50 of essential oil in rats 1500 mg/kg. LD-50 of Valerenone in rats and ice 3g/kg.
Physico Chemical Properties:
|(b)||50% v/v alcohol||Minimum 70.0%|
|Total Ash||Maximum 10.0%|
|Moisture Content||Maximum 5.0%|
|(a)||Total plate count||<1000 cfu/g|
|(b)||Yeast and Moulds||<1000 cfu/g|
|(d-2)||Solvent Residue||Maximum 2 ppm.|