Product Details
Valerian Extract
Description:
Therapeutic Indications:
Valerian Root Extract is:
1. A general tranquilizer used for relieving nervous tension, insomnia and headache.
2. It is Anti-anxiety, anti-stress.
3. Hypotensive.
4. Menopausal disturbances.
5. Nervine tonic.
6. Nervous gastralgia.
Uses and Advance Studies:
| Product | Valerian Wallichii Dry Extract. |
|---|---|
| Description | Dark brown coloured powder with Characteristic odour. |
| Test Solution | Dissolve 0.25 g. extract in 25 ml pure methanol by warming on a water bath, filter and concentrate to 5ml. |
| Solvent System | Toluene-Ethyl Acetate (93:7) |
| Spray Reagent | Hydrochloric acid-Acetate Acid reagent. |
| Evaluation | The TLC picture of Extract is identical with that of standard Valerian Root (Three blue spots). |
Main constituent:
Toxicity and Safety Aspects:
Valerian Root Extract has been reported to be safe, however, low order toxicity has been reported for an ethanolic extract. When extract was administered intraperitoneally to rats in a dose of 400 mg – 600 mg/kg daily for 45 days, no significant changes in weight, blood and urine were observed.
When Valerenic acid was given intraperitonelly to mice, the following results were observed.
50 mg/kg reduced spontaneous motility.
100 mg/kg caused ataxia.
150-200 mg/kg caused muscle spasm.
400 mg/kg caused heavy convulsions leading to death.
LD-50 of extract in mice by intraperitoneal injection 3.3 g/kg.
LD-50 of essential oil in rats 1500 mg/kg. LD-50 of Valerenone in rats and ice 3g/kg.
Physico Chemical Properties:
Solubility:
| (a) | Water | Minimum 70.0% |
|---|---|---|
| (b) | 50% v/v alcohol | Minimum 70.0% |
Assay:
| Valepotriates | Minimum 6.0% |
|---|---|
| Total Ash | Maximum 10.0% |
| Moisture Content | Maximum 5.0% |
Microbiological Test:
| (a) | Total plate count | <1000 cfu/g |
|---|---|---|
| (b) | Yeast and Moulds | <1000 cfu/g |
| (c) | Coliforms | Negative. |
| (d) | Salmonella/Shigella: | Negative. |
| (d-1) | Aflatoxin | Negative. |
| (d-2) | Solvent Residue | Maximum 2 ppm. |
| (d-3) | Pesticidal Residue | Nil. |